+1b Regions Affected by Head Injury (Possible)
+2 Cognition Problems and Compensation
+3 Neurological Dysfunction
2 Effects and Systems Effects
Behavioral, Neurobehavioral and Psychiatric changes from head injury
Hypocretin (Orexin) Neurons
Impact of Traumatic Brain Injury on Dopaminergic Transmission
Impact of Traumatic Brain Injury on Neurotransmitter Systems
Initiation of Inflammation after TBI
Long Term Sequelae of TBI
Metabolic Changes from TBI
Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies
Neuroendocrine changes from TBI
One of the most common characteristics of frontal lobe damage is difficulty in interpreting feedback from the environment.
Onset, Patient History of Illness and Triggers
Paroxysmal Sympathetic Hyperactivity after Acquired Brain Injury
Pharmacological Medicine for Traumatic Brain-injury Rehabilitation by class
post TBI Diabetes Insipidus
pTBI-CF Factors contributing to chronic fatigue after traumatic brain injury
Sleep Disturbance After Traumatic Brain Injury (TBI)
syndrome of inappropriate antidiuretic hormone (SIADH)
The primary brain regions sensitive to acute exercise and symptoms of Post Exertional Malaise are the inferior frontal, parietal and cingulate cortices (regions critical for efficient cognitive processing involving processes associated with attention, error detection, and cognitive control/central executive functions)
Traumatic Brain Injury, Sleep Disorders, and Psychiatric Disorders: An Underrecognized Relationship
1 Changes from Head Injury Testing
3 Back to General Report (Changes from Head Injury)
Physical trauma (eg: car accident)
Pseudo Neurological Damage (Pre Existing and/or Causal to CFS)
+3 Comorbid Mental Health Conditions
+3b Neuroimmune and neuroendocrine processes
1a Decreases in Sphingolipid, glycosphingolipid, phospholipid, purine, microbiome aromatic amino acid and branch chain amino acid metabolites, as well as in flavine adenine nucleotide (FAD) and lathosterol
1b) Stress Response System
1 Brain Regions and Specific Classes/Systems
1 Consistent Abnormalities found in CFS patients
1 Metabolism and Energy Production Dysfunction
2 Orthostatic/neurally Mediated Hypotension/Postural orthostatic tachycardia syndrome (POTS)
2 Testing, Testing Laboratories, Treatment Centers, Specialists and Clinics
3 Drugs used for CFS (and CFS cofactors)
3 Similarly, the HPA axis also interacts with various other glandular systems, among them those producing reproductive hormones, growth hormones, and thyroid hormones. Once activated, the stress response switches off the hormonal systems regulating growth, reproduction, metabolism, and immunity. Short term, the response is helpful, allowing us to divert biochemical resources to deal with the threat.
4 Drugs used for TBI (also helpful for CFS)
4 Immune System Modulators
4 Non Allopathic Treatments of Interest
5 Histaminergic neurons of the hypothalamic tuberomammillary nucleus constitute a major wake‐promoting system
5 Hormone Replacement Therapy (HRT)
5 Sympathetic Dominance/Hyperactivity
Altered central nervous system signal during motor performance in chronic fatigue syndrome.
Amisulpride (very low dose)
and hippocampus in CFS/ME patients
Atomoxetine (Strattera, Attentin)
Blood Brain Barrier and disorders
Brain Fog, Confusion, Sensory overstimulation, memory difficulties, pseudopsychopathy, High Effort in processing Planning Administrative Executive Function Planning Anxiety Stress Passive vs Proactive Shy Withdrawn Uncertain w social self esteem and anxiety etc Dysthymia etc
InComplete List of Treatments (by polling)
Cortical Glutathione and Reductions in the levels of cortical GSH
Corticotropin Releasing Factor Receptor type 2 agonist CT38
Decreased Activation of Subcortical Brain Areas in the Motor Fatigue State: An fMRI Study
Doxepin (Sinequan, Sinquan, Zonalon, Deptran, Xepin)
Excessive sweating, Fatigue, Frequent nighttime urination and Night sweats
Felbamate (Felbatol, Taloxa)
From CFS Unravelled by Dan Neuffer
GH-IGF-I axis abnormalities
HGH (Growth Hormone) and Growth Hormone Deficiency (GHD)
Homeostasis is Dynamic Equilibrium within and without Internal and Environment
Hypothalamic Pituitary Adrenal Axis (Dysfunction)
Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis
Imunovir (inosine pranoxbex)
Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors.
irritable bowel syndrome (IBS)
Jaw bone cavitation infection
Julien & Patricia Regimen
Lack of Proper Probiotic, Prebiotics and/or Enzymes (in Intestines or diet) and/or fiber
LDN (Low-dose naltrexone)
Leaky gut (intestinal permeability)
Less efficient and costly processes of frontal cortex
Neuropeptides, Hormone Like
Overexpending for task Drain on resources
Peptides LL-37 + BPC-157 1
Phenytoin (Dilantin, Hydantin, Phenytek, Epanutin)
Prescriptions used in conjunction
Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome
Psychological/Psychiatric
Reduced Connectivity between the Supplementary Motor Area and Sensorimotor Cortex
Rituximab (Rituxan, Ritumax)
Routine cognitive processes are experienced as unduly effortful and Brain Fog
Structural brain abnormalities and Neuroimaging Abnormalities
Suramin (https://www.healthrising.org/blog/category/treatment/drugs/suramin/ "Suramin is anti-purinergic drug usually used to treat African sleeping sickness and river blindness. Dr. Naviauw believes Suranim may be able to turn off the "cell danger response" in ME/CFS and autism. A small Suramin autism trial was successful. ") (2)
TBI increases mitochondrial fission and that inhibition of fission improves hippocampal-dependent learning and memory
Testing for amount and kind of brain cells by evaluating R2t* signal from MRI scan
The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia
Treatment with Flumazenil (GABAA receptor antagonist)
Vasoactive Neuropeptide Dysfunction (including vasoactive intestinal peptide (VIP) and pituitary adenylate activating polypeptide (PACAP))
Vivid dreams and talking in sleep
What it feels like and how to explain to family and friends
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