1 Circulatory Impairment, Disease and Irregularities
+4 White Blood Cells/Leukocytes/Mast Cells/Immune Cells
10 Peptides and Neuropeptides
Abnormal Nocturnal Heart Rate Variability
Abnormalities in Cerebral Perfusion
Blood cells in chronic fatigue syndrome are drained of energy
Cardiovascular Preload Issue
Cerebral Blood Flow is Decreased in CFS
Compensated Idiopathic Cardiomyopathy (A Model)
defective vasoconstriction producing POTS in CFS (with cardiac autonomic changes as a secondary response)
Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients
Eripheral blood mononuclear cells (PBMCs)
High White Blood Cell Count
Impaired ACh-Mediated Vasodilatation and ACh endothelial sensitivity/Dysfunction
Intracranial Compliance (ICC)
Low Blood Volume (Hypovolemia)
Lower ambulatory blood pressure
Lower Systolic Blood Pressure (and exaggerated diurnal variation)
Orthostatic intolerance (OI)
Poor Erythrocyte Deformability
Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome
Reduced Absolute Cortical Blood Flow in CFS
Systemic Exertion Intolerance
1 Consistent Abnormalities found in CFS patients
2 Circulatory System, Blood Pressure, Blood Volume and Blood Pressure Signaling Effects
12 Abnormal Findings concerning the Cardiovascular System
+3 Comorbid Mental Health Conditions
+3 Neurological Dysfunction
+3b Neuroimmune and neuroendocrine processes
1a Decreases in Sphingolipid, glycosphingolipid, phospholipid, purine, microbiome aromatic amino acid and branch chain amino acid metabolites, as well as in flavine adenine nucleotide (FAD) and lathosterol
1 Abnormalities in bioenergetic function
1 Brain Regions and Specific Classes/Systems
2 of the Circulatory System, Common Comorbid Diseases (Common) and Uncommon Causal Diseases (Uncommon)
2 Orthostatic/neurally Mediated Hypotension/Postural orthostatic tachycardia syndrome (POTS)
2 Treatment for Circulatory System, Blood Volume and Blood Pressure Signaling Effect Abnormalities
3 Alterations in normal energy metabolic processes and abnormalities in cellular bioenergetics
3 DNA and Genetic/Epigenetic Factors
4 Common Comorbid Diseases (Common) and Uncommon Causal Diseases (Uncommon)
4 Endocrine system (and alterations to system)
5 Gastroenterology, Digestive and Urological
5 Sympathetic Dominance/Hyperactivity
9 Disrupted Th1 - Th2 homeostasis (Th2 dominance)
9 Hypometabolic state (as evident in plasma and serum metabolomics)
11b Half of CFS patients (appear to) have a previously undiagnosed medical condition, most often diabetes, CVD and thyroid diseases
14 reported deficiencies in the urea and the TCA cycles, (ornithine/citrulline and pyruvate/isocitrate ratios)
19 Steroidogenic Pathways
Abnormalities in CFS (listing of 1,000 studies in Fourty Five Catagories)
Abnormalities in Cortico-basal Ganglia-thalamo-cortical Loops
Abnormalities in lymphocyte function in CFS
Abnormalities of AMPK activation and glucose uptake
Abnormalities of Gene Expression in the Blood
Abnormalities of stress system activation have been shown in inflammatory diseases such as rheumatoid arthritis, as well as behavioural syndromes such as melancholic depression
Autoimmune and Metabolic Pathway Abnormalities
Blood Brain Barrier and disorders
Brain Fog, Confusion, Sensory overstimulation, memory difficulties, pseudopsychopathy, High Effort in processing Planning Administrative Executive Function Planning Anxiety Stress Passive vs Proactive Shy Withdrawn Uncertain w social self esteem and anxiety etc Dysthymia etc
Central nervous system and hormone abnormalities
Cortical Glutathione and Reductions in the levels of cortical GSH
Dysregulation of acetylcholine and adrenergic signalling
Excessive sweating, Fatigue, Frequent nighttime urination and Night sweats
GH-IGF-I axis abnormalities
Grey matter abnormalities
Hypocortisolemia, Hypocortisolism
Impaired ACh-Mediated Vasodilatation and Endothelial Dysfunction
Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis
irritable bowel syndrome (IBS)
Medial prefrontal cortex deficits and unrefreshing sleep
Mitochondrial Inhibition, Damage and Hypometabolism
Neurotransmitters and Neurotransmitter Systems
Overview of the current understanding of the associations between ME/CFS and metabolic disease by Erifili Hatziagelaki, MD, PhD, Maria Adamaki, PhD, Irene Tsilioni, PhD, George Dimitriadis, MD, Theoharis C. Theoharides, MS, MPhil, PhD, MD
Postural orthostatic tachycardia syndrome
reduced adrenal responsiveness to ACTH
Reduction of serotonin transporters of patients with chronic fatigue syndrome
Routine cognitive processes are experienced as unduly effortful and Brain Fog
Spinal Fluid Abnormalities in Patients with Chronic Fatigue Syndrome
Structural brain abnormalities and Neuroimaging Abnormalities
The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia
White matter abnormalities
No more concurrent uploads are allowed - wait until at least one has finished.
1 Circulatory Impairment, Disease and Irregularities