2 Dysfunction Cycles Syndrome theory

2 Orthostatic/neurally Mediated Hypotension/Postural orthostatic tachycardia syndrome (POTS)

2 Testing, Testing Laboratories, Treatment Centers, Specialists and Clinics

3 Alterations in normal energy metabolic processes and abnormalities in cellular bioenergetics

4 Treatment Protocols

5 Data Resources

5 Sympathetic Dominance/Hyperactivity

6 Metabolism

7 Systems Model

8 Chronic Immune Activation

A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications

Compensated Idiopathic Cardiomyopathy (A Model)

Hypochlorhydria + Dysbiosis + Chronic inflammation = Acquired Mitochondrial Damage

Immune suppression with active opportunistic infections

Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors.

Key Terms

Kindling and Oxidative Stress

Kindling Theory

Medical Hypothesis

Metabolomics

Most Effective Treatments

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus

Neuro-immune Model

Neuroanatomical Model of Fatigue

Overview of the current understanding of the associations between ME/CFS and metabolic disease by Erifili Hatziagelaki, MD, PhD, Maria Adamaki, PhD, Irene Tsilioni, PhD, George Dimitriadis, MD, Theoharis C. Theoharides, MS, MPhil, PhD, MD

Patient Model

Pins

RCCX Hypothesis

Sleep Disturbances, CFS as sleep disorder

Stimulation of Hypothalamic Mast Cells by Environmental Neuroimmune Pathogenic And stress triggers activates microglia leading to focal inflammation in the brain

Sympathetic/Autonomic/HPA Axis/Immune/Gastroenterology Model

The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia